Journal of Computational & Applied Research in Mechanical Engineering (JCARME)

Articles in Press

Document Type : Research Paper

Authors

Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran

https://doi.org/10.22061/jcarme.2025.11625.2555

Abstract

Cancer is a common and often devastating disease affecting many individuals. This condition is frequently perceived as incurable; however, scientific advancements have shown that most cancers are treatable if detected early. The first step in diagnosing cancer is often identifying circulating tumor cells in the bloodstream. Separator devices are employed for the identification of cancer cells. Currently utilized devices are often bulky and marker-based and may come with a biohazard exposure risk. The advancement of micro elector mechanical systems (MEMS) has given rise to smaller devices capable of markerless separation; however, these devices have not yet attained the performance level of conventional devices. Designing a device that can reliably isolate these rare cells is a challenging task. Designing a device that can reliably isolate cancer cells with a high degree of confidence is crucial. In this study, we present a method for model preparation capable of simulating multiple physics. Subsequently, we introduce an optimization process for mesh size. We aim to investigate the design parameters for a novel cell separation device based on buoyancy and a chevron channel. This device has the potential to increase the purity of separators by 10% increase overall acoustic pressure and decrease shear drag. Chevron channel flow pattern if properly aligned can contribute to cell separation of acoustic radiation force or counteract it if necessary. Utilizing buoyancy force for cell separation based on cell density is a prominent feature of acoustic-chevron separator devices. Finally, chevron channel capabilities and design constraints are discussed.

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References

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Journal of Computational & Applied Research in Mechanical Engineering (JCARME)

Articles in Press, Corrected Proof
Available Online from 11 November 2025

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