Micro and Nano Systems
A. A. Naseri; N. Naserifar
Abstract
Cancer is a common and often devastating disease affecting many individuals. This condition is frequently perceived as incurable; however, scientific advancements have shown that most cancers are treatable if detected early. The first step in diagnosing cancer is often identifying circulating tumor cells ...
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Cancer is a common and often devastating disease affecting many individuals. This condition is frequently perceived as incurable; however, scientific advancements have shown that most cancers are treatable if detected early. The first step in diagnosing cancer is often identifying circulating tumor cells in the bloodstream. Separator devices are employed for the identification of cancer cells. Currently utilized devices are often bulky and marker-based and may come with a biohazard exposure risk. The advancement of micro elector mechanical systems (MEMS) has given rise to smaller devices capable of markerless separation; however, these devices have not yet attained the performance level of conventional devices. Designing a device that can reliably isolate these rare cells is a challenging task. Designing a device that can reliably isolate cancer cells with a high degree of confidence is crucial. In this study, we present a method for model preparation capable of simulating multiple physics. Subsequently, we introduce an optimization process for mesh size. We aim to investigate the design parameters for a novel cell separation device based on buoyancy and a chevron channel. This device has the potential to increase the purity of separators by 10% increase overall acoustic pressure and decrease shear drag. Chevron channel flow pattern if properly aligned can contribute to cell separation of acoustic radiation force or counteract it if necessary. Utilizing buoyancy force for cell separation based on cell density is a prominent feature of acoustic-chevron separator devices. Finally, chevron channel capabilities and design constraints are discussed.
Micro and Nano Systems
Azadeh Shahidian; Sanam Tahouneh
Abstract
In recent years, microfluidic devices have had various applications, such as the biological field. Hence, it is essential to study fluid flow governing equations in order to realization and ability to better control fluids in different flow regimes according to microfluidic devices. Also, study of inducing ...
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In recent years, microfluidic devices have had various applications, such as the biological field. Hence, it is essential to study fluid flow governing equations in order to realization and ability to better control fluids in different flow regimes according to microfluidic devices. Also, study of inducing source, fabrication technique, and numerical procedure of fluid flow simulation are necessary for flow solution and are used to select proper devices.Here, the mentioned cases have been studied. As well, numerical methods of fluid flow study for various type of fluid, their comparison and pros and cons of each of them have been briefly expressed that may be used for the development of them. Then, the extensive biological application of micromixers and micropumps have been investigated. It is expected that this paper will be of attention to scholars or practitioners in the micromixer and micropump biomedical technology field and those who enter this context for the first time and may also highlight what will assist in future development.
Micro and Nano Systems
Aylar Khooshehmehri; Abdollah Eslami Majd; Elham Arabsheybani
Abstract
The hemispherical resonator gyro (HRG) is a type of precision inertial sensor that has the advantages of direct angle measurement and unlimited dynamic range. The overall accuracy of the HRG is due to the quality of its resonator shell, and improving the performance of resonators requires a proper understanding ...
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The hemispherical resonator gyro (HRG) is a type of precision inertial sensor that has the advantages of direct angle measurement and unlimited dynamic range. The overall accuracy of the HRG is due to the quality of its resonator shell, and improving the performance of resonators requires a proper understanding of the processes of energy damping in each resonance cycle, which has a significant impact on sensor performance. In this paper, in order to investigate the losses in the hemisphere shell resonator, first, the equations governing the shell are studied, and three-dimensional modeling is performed in COMSOL software. By performing mechanical simulations, the resonance modes and the natural frequency of the shell are investigated, and finally, the second and third resonance modes are selected as the optimal operating mode of the gyroscope. Also, by performing thermal simulations, the dominant energy damping processes, such as thermo-elastic damping and anchor loss were analyzed and simulated, and the effect of shell material on damping was investigated. Then the quality factor of the resonator was evaluated based on its geometry and material. In this way, according to the scope of work of the gyroscope, this process can be used to design the specifications of the shell to achieve a resonator with the desired quality factor.
Micro and Nano Systems
Seyyed Mohammad Fatemi; Yaghoub Tadi Beni
Abstract
Using differential quadrature method, this study investigated pull-in instability of beam-type nano-switches under the effects of small-scale and intermolecular forces including the van der Waals and the Casimir forces. In these nano-switches, electrostatic forces were served as the driving force, and ...
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Using differential quadrature method, this study investigated pull-in instability of beam-type nano-switches under the effects of small-scale and intermolecular forces including the van der Waals and the Casimir forces. In these nano-switches, electrostatic forces were served as the driving force, and von-Karman type nonlinear strain was used to examine nonlinear geometric effects. To derive nonlinear governing equations as well as the related boundary conditions for the nano-beam, variation method was used. Besides, to study the influence of size effect, the nonlocal elasticity theory was employed and the resulting governing equations were solved using differential quadrature method. Finally, the pull-in parameters were studied using the nonlocal theory and the results were compared with the numerical results of the classical continuum theory as well as experimental results contained in the references. Results demonstrated that taking into consideration the von-Karman type nonlinear strain increases the beam stiffness and hence, the pull-in voltage. Besides, use of the small scale, compared with the classical theory of elasticity, yields results much closer to experimental results.
